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Paronychia (Infection Beside the Nail)

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Overview¶
Paronychia is an infection of the nail fold that may involve bacterial or fungal pathogens. Staphylococcus pyogenes and Candida albicans are frequently cultured from infected nail folds in chronic paronychia [1]. However, Candida eradication was not associated with clinical cure in most patients with chronic paronychia, indicating that Candida is just a colonizer of the proximal nail fold [8]. Chronic keratinaceous paronychia should be regarded as a potential complication of nail biting [2]. Fungal infections of the hand are most commonly cutaneous infections involving the skin and nails and can be treated with topical or local therapy [7].
Simple procedures should be tried first in almost every case of paronychia, as many patients may be cured without recourse to nail removal [6]. Severe paronychia can be treated by burning holes through the nail with a heated wire to drain pus, resulting in instant relief and return to full duty by the fifth morning [4]. Chemical sealing of the proximal nail fold with cyanoacrylate glue allows the gap between the proximal nail fold and nail plate to heal and fill up within 6–8 weeks, providing relief from chronic paronychia [5]. Fifty-nine patients with proved monilial paronychia were treated with the nail polish sealer method [17].
Chronic paronychia required on average 20.4 ± 18.32 days of low-level laser therapy (LLLT) to reach the treatment endpoint [10]. En bloc excision of the proximal nail fold is a useful method for treating recalcitrant chronic paronychia [3]. In a small study of chronic paronychia treatment, all patients improved at the same rate, suggesting that care of the nail folds is more important than the medication applied [25].
Anatomy & Pathophysiology¶
Hand and upper-extremity infections are primarily clinical diagnoses [26], though imaging and laboratory evaluation aid in diagnosis [26]. These infections encompass a diverse array of entities with potential for serious morbidity [27]. Most result from neglected minor wounds [48] and are associated with a high rate of complications that are often difficult to manage [47]. Prompt diagnosis and early treatment are necessary to prevent complications such as hand stiffness, contractures, and amputation [35].
Physicians must consider the unique environments and characteristics of the pediatric hand, including the frequency of fingers in mouths, open growth plates, and typically more robust circulation with fewer systemic comorbidities [46].
The review discusses the surface, gross, and microscopic anatomy of the distal digit to facilitate surgical procedures in the nail unit with minimal residual impact [45]. Proper direction of incisions helps ensure proper direction of healing, which determines whether scarring of the nail bed/matrix occurs [49]. The distal phalanx has a dual blood supply [51].
Classification¶
Chronic Paronychia: Chronic paronychia is an inflammatory disorder of the nail folds [15]. Chronic keratinaceous paronychia is a potential complication of nail biting [2]. In children, chronic paronychia is predominantly associated with thumb-sucking, which causes maceration and creates a pocket for organisms like Candida albicans [13]. In adults, it is commonly seen in housewives and housemaids, resulting from exposure to irritants and allergens [15]. The mechanisms of infection, trauma, and prolonged immersion of the hands in water are not sufficient to explain the chronic forms of paronychia [9]. Candida is a colonizer of the proximal nail fold, as Candida eradication was not associated with clinical cure in most patients [8]. Candida paronychia is very uncommon except for patients with chronic mucocutaneous candidiasis and HIV infection [20].
Onychomycosis: Onychomycosis is the most common single cause of nail dystrophy [32]. It has a marked impact on quality of life, with patients reporting both functional and psychosocial impairment associated with their disease [32]. Affected nails in onychomycosis can disrupt the integrity of surrounding skin and increase the risk of secondary bacterial infection [32]. Fungal infections of the hand are most commonly cutaneous infections involving the skin and nails [7]. Candida and nondermatophyte infections often involve the surrounding nail folds, causing paronychia in addition to nail plate disease [19]. Classification of onychomycosis includes superficial white, proximal subungual, distal subungual, and total dystrophic types [19]. Classification is determined from an examination of the nail [19]. Classifying onychomycosis offers clues to a causative organism and can guide treatment strategy and determine prognosis [19].
Superficial White Onychomycosis: Superficial white onychomycosis involves the nail plate and is a direct infection of the surface of the nail [19]. It presents as a chalky white appearance or white, powder-like scale on the surface of the nail plate that can be scraped off with a scalpel or microscope slide [19]. Superficial white onychomycosis is the most common presentation in the pediatric population [19]. Common infecting organisms include T. mentagrophytes and the nondermatophytes Aspergillus and Fusarium [19]. Superficial white onychomycosis can be treated with topical antifungals [19].
Proximal Subungual Onychomycosis: Proximal subungual onychomycosis is characterized by white discoloration at the proximal nail fold [32]. In this subtype, the white areas are within the nail plate [19]. The diagnosis can be confirmed by potassium hydroxide or cultures of parings off the plate [19]. Proximal subungual onychomycosis implies increased susceptibility to dermatophyte infection because of immunosuppression or greater susceptibility to chronic dermatophyte infection [19]. Proximal subungual onychomycosis is treated with systemic antifungals [19].
Distal Subungual Onychomycosis: Distal subungual onychomycosis is characterized by a thickened nail with white-yellow discoloration, subungual debris, and onycholysis [32].
Total Dystrophic Onychomycosis: Total dystrophic onychomycosis represents the most severe involvement of the nail, which can become thickened, dystrophic, and discolored in all subtypes [19].
Other Considerations: If the nail is white, one should consider superficial white or proximal subungual onychomycosis [19]. The clinical differential diagnosis of a new periungual or subungual lesion (with or without an associated nail plate dystrophy) should include tumor metastasis to the nail unit not only in oncology patients, but also in previously cancer-free individuals [14].
Clinical Presentation¶
Paronychia is a common inflammatory condition of the nail fold often associated with infection, encompassing fungal, viral, or bacterial etiologies [31]. Chronic paronychia is defined by symptoms present for more than 6 weeks at the time of diagnosis [18]. Patients typically report erythema, swelling, and pain, though the degree of erythema and swelling is often less severe than that seen in acute paronychia [18]. Symptoms may undergo episodic exacerbation, frequently following exposure to moist environments [18].
Inspection reveals that the proximal nail fold in chronic cases may become raised and separated from the underlying nail [18]. Associated nail changes can include ridging, grooving, discoloration, and/or rounding of the nail plate [18]. The underlying cause is generally attributed to prolonged exposure to cold water, which allows Candida and Pseudomonas species to act as opportunist pathogens [16]. However, Candida eradication was not associated with clinical cure in most patients, indicating that Candida acts primarily as a colonizer of the proximal nail fold [8]. This is supported by findings where all patients had positive C. albicans cultures from the nail fold before biopsy, while Littman’s cultures from the dermis were negative [30].
In children, chronic paronychia is predominantly associated with thumb-sucking [13]. This habit causes maceration and creates a pocket for organisms like Candida albicans [13]. Neonatal paronychia represents a rare presentation of acute bacterial paronychia caused by clindamycin-resistant Staphylococcus aureus [31].
Atypical chronic sterile paronychia can lead to tissue and joint space destruction in patients with thromboangiitis obliterans [11]. Persistent, active inflammation, compromised vasculature, poor hand hygiene, poor healing, and a reluctance to seek treatment may allow paronychia to evolve and erode into the joint space [11].
The clinical differential diagnosis of a new periungual or subungual lesion with or without associated nail plate dystrophy should include tumor metastasis to the nail unit [14]. Physicians should consider squamous cell carcinoma of the nail unit in each case of a nail abnormality unresponsive to topical treatment [23].
Investigations¶
Laboratory: Chronic paronychia is frequently associated with cultures positive for Staphylococcus pyogenes and Candida albicans [1]. Fungal infections of the hand can be treated with topical or local therapy [7]. In oncology patients and previously cancer-free individuals, the clinical differential diagnosis of a new periungual or subungual lesion with or without associated nail plate dystrophy should include tumor metastasis to the nail unit [14]. Physicians should consider squamous cell carcinoma of the nail unit (SCCNU) in each case of a nail abnormality unresponsive to topical treatment [23].
Procedural & Clinical Assessment: A simple procedure should be tried first in almost every case of paronychia, as many patients may be cured without recourse to nail removal [6]. Nail removal should be performed for the surgical treatment of chronic paronychia when concurrent nail irregularities are seen [21]. Severe paronychia can be treated by burning holes through the nail with a heated wire to drain pus [4]. The Swiss roll technique is a simple method for the treatment of chronic and severe acute paronychia with run around infection involving both nail folds [29].
Other Considerations: Atypical chronic sterile paronychia can evolve and erode into the joint space in patients with thromboangiitis obliterans, driven by persistent inflammation, compromised vasculature, poor hand hygiene, poor healing, and reluctance to seek treatment [11]. Complications associated with mycobacterial hand infections can be significant [42]. Early osteomyelitis of the bone can be detected long before roentgenograms reveal evidence of destruction in closed space infections involving the distal phalanx [43]. The direct flow island flap is superior in terms of outcome for nail bed regeneration, regardless of age, sex, affected finger, dominant hand, type of trauma, and injury zone [28]. A randomized phase 2 trial evaluated the efficacy of twice daily 1% or 2% PVP-I topical solution versus vehicle-control in adult patients with cancer therapy-associated paronychia [12]. The primary objective of the PVP-I trial was to evaluate efficacy as evidenced by a two-grade reduction (or reduction to grade 0 if involved nails were grade 1) on the six-point Paronychia Severity Grading (PSG) scale [12]. Secondary objectives of the PVP-I trial assessed the impact on quality of life, the antimicrobial effect from baseline bacterial cultures, and nail clippings for fungus identification [12].
Treatment¶
Non-Operative Management¶
Topical or local therapy is an established treatment for fungal infections of the hand, including those involving the skin and nails [7]. For chronic paronychia, fluconazole at a dose of 50 mg/day is effective and safe [22]. In contrast, terbinafine shows no significant difference in efficacy compared to placebo in candidal nail disease after 12 weeks of therapy [33]. Alternative non-pharmacologic approaches include the nail polish sealer method, which was used to treat 59 patients with proved monilial paronychia [17]. Chemical sealing of the proximal nail fold with cyanoacrylate glue allows the gap between the proximal nail fold and nail plate to heal and fill within 6–8 weeks, providing relief from chronic paronychia [5]. Low-level laser therapy (LLLT) is also utilized, requiring an average of 20.4 ± 18.32 days to reach the treatment endpoint [10].
Operative and Procedural Management¶
Initial Intervention: A simple procedure of lifting the cuticle and inserting a sterile rubber ribbon should be tried first in almost every case of paronychia, as many patients may be cured without nail removal [6]. This technique can arrest and cure early paronychia in a few days without nail removal [40].
Drainage and Flap Techniques: A simple technique of draining acute paronychia can be used as a drainage procedure and part of the management of acute paronychia [39]. For chronic and severe acute paronychia with run-around infection involving both nail folds, the Swiss roll technique is a simple method [29]. The square flap technique cured paronychia in all but 2 cases, as measured by cuticle regrowth [34].
Clinical Course and Complications¶
Chronic paronychia typically presents with erythema, swelling, and pain, with symptoms present for more than 6 weeks at the time of diagnosis [18]. Episodic exacerbation of chronic paronychia symptoms can occur and may follow exposure to moist environments [18]. Atypical chronic sterile paronychia can evolve and erode into the joint space in patients with thromboangiitis obliterans due to persistent inflammation, compromised vasculature, poor hand hygiene, poor healing, and reluctance to seek treatment [11].
Complications¶
Infection: Chronic paronychia is an inflammatory disorder of the nail folds, commonly seen in housewives and housemaids, resulting from exposure to irritants and allergens [15].
Recovery¶
Light activity (weeks): Evidence does not specify a week range for return to desk work, driving, or light activities of daily living.
Full activity (months): Evidence does not specify a month range for return to manual work, sport, or full range of motion and strength.
Complete recovery / outcome plateau (months): Chemical sealing of the proximal nail fold with cyanoacrylate glue results in healing and filling of the gap between the proximal nail fold and nail plate within 6–8 weeks, providing relief from chronic paronychia [5]. Low-level laser therapy (LLLT) for chronic paronychia required an average of 20.4 ± 18.32 days of therapy to reach the treatment endpoint [10].
Rehabilitation protocol: Evidence does not specify physical therapy phasing, immobilisation duration, weight-bearing or range of motion progression, or sling/brace removal timing.
Functional milestones: A novel topical povidone-iodine formulation (1% or 2%) was evaluated for efficacy in cancer therapy-associated paronychia, with the primary objective being a two-grade reduction on the Paronychia Severity Grading scale [12]. Candida eradication was not associated with clinical cure in most patients with chronic paronychia, indicating that Candida acts as a colonizer of the proximal nail fold rather than a primary pathogen [8].
Other Considerations: No additional recovery-relevant content, such as predictors of return-to-work failure or patient-selection caveats for early range of motion, is specified in the evidence.
Key Evidence¶
- [L5] The paper reviews the aetiology and treatment of chronic paronychia, noting that Staphylococcus pyogenes and Candida albicans are frequently cultured from infected nail folds. [1] (10.1136/bmj.4.5730.257)
- [L5] Chronic keratinaceous paronychia should be regarded as a potential complication of nail biting. [2] (10.1136/bmj.280.6208.189-g)
- [L2] En bloc excision of the proximal nail fold is a useful method in recalcitrant chronic paronychia. [3] (10.1111/j.1524-4725.2006.32079.x)
- [L5] The author reports a single case of severe paronychia treated by burning holes through the nail with a heated wire to drain pus, resulting in instant relief and the patient returning to full duty by the fifth morning. [4] (10.1136/bmj.2.4417.299-a)
- [L4] The gap between the proximal nail fold and nail plate heals and fills up within 6–8 weeks, providing relief from chronic paronychia. [5] (10.25259/csdm_132_2023)
- [L5] The author believes that this simple procedure should be tried first in almost every case, as many patients may be cured without recourse to nail removal. [6] (10.1056/nejm193412062112313)
- [L5] Fungal infections of the hand are most commonly cutaneous infections involving the skin and nails and can be treated with topical or local therapy. [7] (10.1016/j.hcl.2020.03.009)
- [L1] Candida eradication was not associated with clinical cure in most patients, indicating that Candida is just a colonizer of the proximal nail fold. [8] (10.1067/mjd.2002.122191)
- [L4] The author describes the principal clinical characteristics of paronychia and reviews its pathogenesis, stressing the fact that the mechanisms of infection, trauma and prolonged immersion of the hands in water, are not sufficient to explain the chronic forms of the disease. [9] (10.1159/000255443)
- [L4] Chronic paronychia required on average 20.4 ± 18.32 days of therapy to reach the treatment endpoint. [10] (10.5978/islsm.10.133)
- [L5] The combination of persistent, active inflammation, compromised vasculature, poor hand hygiene, poor healing and a reluctance to seek treatment may well have allowed the paronychia to evolve and erode into the joint space. [11] (10.1111/j.1440-0960.2012.00967.x)
- [L2] [12] (10.1007/s10637-019-00825-0)
- [L4] Chronic paronychia in children is predominantly associated with thumb-sucking, which causes maceration and creates a pocket for organisms like Candida albicans. [13] (10.1177/000992286800700213)
- [L4] The clinical differential diagnosis of a new periungual or subungual lesion (with or without an associated nail plate dystrophy) should include tumor metastasis to the nail unit not only in oncology patients, but also in previously cancer-free individuals. [14] (10.1097/00042728-200103000-00014)
- [L4] Chronic paronychia is an inflammatory disorder of the nail folds, commonly seen in housewives and housemaids, resulting from exposure to irritants and allergens. [15] (10.4103/0019-5154.123482)
- [L5] The underlying cause of chronic paronychia is generally agreed to be prolonged exposure to (cold) water, allowing Candida and Pseudomonas species to act as opportunist pathogens. [16] (10.1136/bmj.2.6200.1294-a)
- [L4] Fifty-nine patients with proved monilial paronychia were treated with the nail polish sealer method. [17] (10.1001/archderm.1955.03730340045008)
- [L5] [18] (10.5435/jaaos-22-03-165)
- [L5] [19] (10.1016/j.jhsa.2013.11.017)
- [L5] Candida paronychia is very uncommon except for patients with chronic mucocutaneous candidiasis and HIV infection, and its diagnosis can only be established on the basis of the results of treatment with systemic antifungals. [20] (10.5070/d32wb4g9wf)
- [L4] Nail removal should be performed when concurrent nail irregularities are seen. [21] (10.1016/s0363-5023(10)80118-2)
- [L4] These results show that 50 mg/day fluconazole is both effective and safe in the management of chronic paronychia. [22] (10.3109/09546639909056029)
- [L4] Physicians should consider SCCNU in each case of a nail abnormality unresponsive to topical treatment. [23] (10.1016/j.jhsa.2018.01.010)
- [L4] Although a small number of patients were treated, they all improved at the same rate; probably because the care of the nail folds is more important than the medication applied. [25] (10.1097/00043764-196606000-00039)
- [L5] Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis. [26] (10.1016/j.hcl.2020.03.002)
- [L5] Hand infections include a diverse array of entities with potential for serious morbidity. [27] (10.1016/j.jhsa.2011.05.035)
- [L4] The direct flow island flap is superior in terms of outcome, regardless of age, sex, affected finger, dominant hand, type of trauma, and injury zone. [28] (10.1177/15589447211064359)
- [L4] The Swiss roll technique is a simple method for the treatment of chronic and severe acute paronychia with run around infection involving both nail folds. [29] (10.1097/bth.0b013e3181ec089e)
- [L4] [30] (10.1001/archderm.1962.01590090066015)
- [L5] [31] (10.1111/pde.15017)
- [L5] [32] (10.1016/j.jhsa.2008.05.028)
- [L1] The results indicate that there is no significant difference in efficacy between terbinafine and placebo in candidal nail disease after 12 weeks of therapy. [33] (10.3109/09546639209088701)
- [L4] The novel method cured paronychia in all but 2 cases, measured by cuticle regrowth. [34] (10.1016/j.jaad.2016.02.1154)
- [L5] Prompt diagnosis and early treatment are necessary to prevent complications such as hand stiffness, contractures, and amputation. [35] (10.1016/j.jhsa.2014.03.031)
- [L4] It can thus be used as drainage procedure and part of management of acute paronychia. [39] (10.1097/01.bth.0000163575.00615.69)
- [L5] Early paronychia can be arrested and cured in a few days without the necessity of nail removal through a conservative method of lifting the cuticle and inserting a sterile rubber ribbon. [40] (10.1056/nejm192511051931904)
- [L4] The complications associated with mycobacterial hand infections can be significant. [42] (10.1177/1558944720940064)
- [L4] Early osteomyelitis of the bone can be detected long before the roentgenogram reveals evidences of destruction. [43] (10.1097/00000658-194001000-00013)
- [L5] This review discusses the surface, gross, and microscopic anatomy of the distal digit to facilitate surgical procedures in the nail unit with minimal residual impact. [45] (10.1097/00042728-200103000-00009)
- [L5] Although many management principles are the same in pediatric and adult patients, physicians should bear in mind the unique environments and characteristics of the pediatric hand, including the frequency of fingers in mouths, open growth plates, and typically more robust circulation with fewer systemic comorbidities. [46] (10.1016/j.hcl.2020.03.012)
- [L5] Hand infections are associated with a high rate of complications that are often difficult to manage. [47] (10.1016/j.hcl.2020.03.010)
- [L4] Most hand infections are the result of minor wounds that have been neglected. [48] (10.1016/j.ijid.2005.06.009)
- [L5] Proper direction of incisions helps ensure proper direction of healing, which determines whether scarring of the nail bed/matrix occurs. [49] (10.4103/jcas.jcas_67_23)
- [L4] The distal phalanx has a dual blood supply, and removal of the major portion of the phalanx and preservation of the base will often give startling results in the regeneration of the phalanx. [51] (10.1001/archsurg.1942.01210240092006)
See Also¶
References¶
[1] Problems of chronic paronychia.. BMJ. 1970. DOI: 10.1136/bmj.4.5730.257
[2] Points: Treatment of chronic paronychia. BMJ. 1980. DOI: 10.1136/bmj.280.6208.189-g
[3] En Bloc Excision of Proximal Nail Fold for Treatment of Chronic Paronychia. Dermatologic Surgery. 2006. DOI: 10.1111/j.1524-4725.2006.32079.x
[4] Treatment of Severe Paronychia. BMJ. 1945. DOI: 10.1136/bmj.2.4417.299-a
[5] Chemical sealing of proximal nail fold with cyanoacrylate glue for accelerated regeneration of nail cuticle as a treatment of chronic paronychia. Cosmoderma. 2023. DOI: 10.25259/csdm_132_2023
[6] Note on the Treatment of Paronychia. New England Journal of Medicine. 1934. DOI: 10.1056/nejm193412062112313
[7] Fungal Infections of the Hand. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.009
[8] Topical steroids versus systemic antifungals in the treatment of chronic paronychia: An open, randomized double-blind and double dummy study. Journal of the American Academy of Dermatology. 2002. DOI: 10.1067/mjd.2002.122191
[9] Pathogenesis and Treatment of Chronic Paronychia. Dermatologica. 2009. DOI: 10.1159/000255443
[10] TREATMENT OF NAIL DISORDERS WITH LLLT (2) CHRONIC PARONYCHIA AND INGROWN NAIL. LASER THERAPY. 1998. DOI: 10.5978/islsm.10.133
[11] Atypical chronic sterile paronychia leading to tissue and joint space destruction in a patient with thromboangiitis obliterans. Australasian Journal of Dermatology. 2012. DOI: 10.1111/j.1440-0960.2012.00967.x
[12] A randomized phase 2 trial of the efficacy and safety of a novel topical povidone-iodine formulation for Cancer therapy-associated Paronychia. Investigational New Drugs. 2019. DOI: 10.1007/s10637-019-00825-0
[13] Chronic Paronychia in Children. Clinical Pediatrics. 1968. DOI: 10.1177/000992286800700213
[14] Metastatic Tumors to the Nail Unit. Dermatologic Surgery. 2001. DOI: 10.1097/00042728-200103000-00014
[15] Management of chronic paronychia. Indian Journal of Dermatology. 2014. DOI: 10.4103/0019-5154.123482
[16] Treatment of chronic paronychia. BMJ. 1979. DOI: 10.1136/bmj.2.6200.1294-a
[17] USE OF NAIL POLISH SEALER IN TREATMENT OF MONILIAL PARONYCHIA. Archives of Dermatology. 1955. DOI: 10.1001/archderm.1955.03730340045008
[18] Acute and Chronic Paronychia of the Hand. Journal of the American Academy of Orthopaedic Surgeons. 2014. DOI: 10.5435/jaaos-22-03-165
[19] Fungal Nail Infections. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2013.11.017
[20] Controversy: the role of yeasts in chronic paronychia: pro. Dermatology Online Journal. 2003. DOI: 10.5070/d32wb4g9wf
[21] Eponychial marsupialization and nail removal for surgical treatment of chronic paronychia. The Journal of Hand Surgery. 1991. DOI: 10.1016/s0363-5023(10)80118-2
[22] Fluconazole 50 mg/day therapy in the management of chronic paronychia. Journal of Dermatological Treatment. 1999. DOI: 10.3109/09546639909056029
[23] Squamous Cell Carcinoma of the Nail Unit: Review of the Literature. The Journal of Hand Surgery. 2018. DOI: 10.1016/j.jhsa.2018.01.010
[25] The Treatment of Chronic Paronychia. Journal of Occupational and Environmental Medicine. 1966. DOI: 10.1097/00043764-196606000-00039
[26] Imaging and Laboratory Workup for Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.002
[27] Hand Infections. The Journal of Hand Surgery. 2011. DOI: 10.1016/j.jhsa.2011.05.035
[28] Does the Nail Bed Regenerate?. HAND. 2021. DOI: 10.1177/15589447211064359
[29] Swiss Roll Technique for Treatment of Paronychia. Techniques in Hand & Upper Extremity Surgery. 2011. DOI: 10.1097/bth.0b013e3181ec089e
[30] Chronic Paronychia. Archives of Dermatology. 1962. DOI: 10.1001/archderm.1962.01590090066015
[31] Acute paronychia in a neonate secondary to clindamycin‐resistant Staphylococcus aureus. Pediatric Dermatology. 2022. DOI: 10.1111/pde.15017
[32] Current Management of Onychomycosis. The Journal of Hand Surgery. 2008. DOI: 10.1016/j.jhsa.2008.05.028
[33] Terbinafine in chronic paronychia and candida onychomycosis. Journal of Dermatological Treatment. 1992. DOI: 10.3109/09546639209088701
[34] Chronic paronychia treatment: Square flap technique. Journal of the American Academy of Dermatology. 2016. DOI: 10.1016/j.jaad.2016.02.1154
[35] Acute Hand Infections. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2014.03.031
[39] DAREJD Simple Technique of Draining Acute Paronychia. Techniques in Hand & Upper Extremity Surgery. 2005. DOI: 10.1097/01.bth.0000163575.00615.69
[40] The Treatment of Early Paronychia. The Boston Medical and Surgical Journal. 1925. DOI: 10.1056/nejm192511051931904
[42] Mycobacterial Infections of the Hand. HAND. 2020. DOI: 10.1177/1558944720940064
[43] NEW INCISION FOR CLOSED SPACE INFECTION (FELON) INVOLVING DISTAL PHALANX OF FINGER. Annals of Surgery. 1940. DOI: 10.1097/00000658-194001000-00013
[45] Surgical Anatomy of the Nail Unit. Dermatologic Surgery. 2001. DOI: 10.1097/00042728-200103000-00009
[46] Pediatric Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.012
[47] Complications of Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.010
[48] Epidemiology of bacterial hand infections. International Journal of Infectious Diseases. 2006. DOI: 10.1016/j.ijid.2005.06.009
[49] Nail unit incision lines: A tool to minimize nail unit scarring. Journal of Cutaneous and Aesthetic Surgery. 2023. DOI: 10.4103/jcas.jcas_67_23
[51] END RESULTS OF A NEW INCISION FOR FELON (INFECTION OF THE ANTERIOR SPACE). Archives of Surgery. 1942. DOI: 10.1001/archsurg.1942.01210240092006